2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140308
    DBCO-PEG4-triethoxysilane 2353410-02-1
    DBCO-PEG4-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-triethoxysilane is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-triethoxysilane
  • HY-141219
    m-PEG11-OH 2168540-65-4 99.83%
    m-PEG11-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG11-OH
  • HY-108372
    Boc-C5-O-C5-O-C6-Cl 1835705-52-6
    Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
    Boc-C5-O-C5-O-C6-Cl
  • HY-130620
    PEG3-C4-OBn 2381196-79-6 99.29%
    PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC.
    PEG3-C4-OBn
  • HY-126884
    DBCO-NHCO-PEG4-NH-Boc 1255942-12-1
    DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG4-NH-Boc
  • HY-W872575
    TCO4-PEG3-Maleimide 1914971-04-2
    TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    TCO4-PEG3-Maleimide
  • HY-133368
    DBCO-NHCO-PEG12-amine
    DBCO-NHCO-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG12-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG12-amine
  • HY-130821
    THP-PEG4-Pyrrolidine(N-Me)-CH2OH 2378261-81-3
    THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).
    THP-PEG4-Pyrrolidine(N-Me)-CH2OH
  • HY-130375
    Propargyl-PEG8-Boc 2055014-96-3
    Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-Boc
  • HY-W019226
    Methyl 1-Cbz-azetidine-3-carboxylate 757239-60-4 99.81%
    Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
    Methyl 1-Cbz-azetidine-3-carboxylate
  • HY-117045
    Propargyl-PEG12-OH 1036204-61-1 ≥98.0%
    Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG12-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG12-OH
  • HY-140574
    N-Mal-N-bis(PEG2-NH-Boc) 2128735-26-0
    N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG2-NH-Boc)
  • HY-140488
    Cbz-NH-PEG3-C2-acid 1310327-18-4 99.82%
    Cbz-NH-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG3-C2-acid
  • HY-140708
    m-PEG-thiol (MW 10000) 98.0%
    m-PEG-thiol (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 10000)
  • HY-141249
    Azido-PEG4-Amido-Tris 1398044-55-7
    Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Amido-Tris is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Amido-Tris
  • HY-141004A
    3,4-Dibromo-Mal-PEG2-amine TFA 2296708-07-9 98.0%
    3,4-Dibromo-Mal-PEG2-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,4-Dibromo-Mal-PEG2-amine TFA
  • HY-W043840
    m-PEG5-CH2CH2COOH 1347750-72-4
    m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-CH2CH2COOH
  • HY-145249
    ATP-PEG8-Biotin
    ATP-PEG8-Biotin is a PEG-based linker that incorporates ATP. ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-PEG8-Biotin
  • HY-140158
    Methylamino-PEG3-azide 1355197-57-7
    Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methylamino-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Methylamino-PEG3-azide
  • HY-133507
    Mal-amide-PEG2-oxyamine 2253965-09-0
    Mal-amide-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amide-PEG2-oxyamine
PROTAC Linkers Isoform Comparison

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